2 time course and reflex nature of the acute cardiorespiratory response to thoracic blast injury
Tài liệu Effect modification of air pollution on Urinary 8-Hydroxy-2’-Deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactions ppt
Ngày tải lên :
17/02/2014, 22:20
... significance of interaction terms of individual SNP and pollutant The current version of MTP allows one to identify the significance of a group of candidate variables to reduce the false discovery rate ... variants of the significant genes identified by MTP with significant interactions using the bootstrap method with the combination of coefficients of the main effect and the interaction [6] Page of ... 145 (48.82) *The sum of the subjects in each genotype may not add up to the total number of subjects due to missing genotyping data Missing genotyping is due to a variable number of samples for...
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Tài liệu Static and Dynamic Analysis of the Internet’s Susceptibility to Faults and Attacks docx
Ngày tải lên :
18/02/2014, 01:20
... snapshots of the real Internet topology.1 On the other hand, [42], [43] have shown that the clustering coefficient of the Internet has been growing and that the average diameter of the Internet ... characteristics of the Internet; , Ko and DIKo are defined as the average diameter, K, and DIK of the original networks and df , Kf and DIKf denote the diameter, K, and DIK after 10% of the nodes are ... (c) DIK Fig Robustness of the Internet, and the BA and GE models under mixed failures after 10% of total nodes are destroyed (a): The average diameter of the Internet and the BA model increases...
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Governance and organizational structure of the inter-agency secretariat to the United Nations International Strategy for Disaster Risk Reduction (ISDR) pot
Ngày tải lên :
23/03/2014, 02:20
... also the Special Representative of the Secretary-General (SRSG) for the implementation of the HFA The mandate of the secretariat is to act as the focal point in the United Nations system for the ... At the same time, the USG also released the Director and the relevant sections of the OCHA Administrative Office in Geneva from the responsibility to oversee and provide financial services to the ... segregation of duties in order to assume the proposed delegation of authority The capacity and the structure needs to be developed based on the analysis of the needs, bottlenecks and strengths of the...
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báo cáo hóa học: " The acute inflammatory response to intranigral a-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation" pptx
Ngày tải lên :
19/06/2014, 22:20
... pathways activated by LPS To date, little comparison of the in vivo inflammatory effects of SNCA and LPS has been made The aim of the present study was to determine the immune profile resulting from ... microinjection of SNCA into the SNpc, the mRNA of the major proinflammatory cytokines, IL-1b, IL-6 and TNFa, were significantly up-regulated compared to the BSA controls (Figure 3) Both eSNCA and BSA ... known to contribute to the progression of many neurological diseases, we were interested to discover whether the activation of the innate immune system by LPS would affect the host response to eSNCA...
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báo cáo khoa học: "Evaluation of the microbial growth response to inorganic nanoparticles" ppt
Ngày tải lên :
11/08/2014, 00:22
... solution allows the nanoparticles to attract to one another because of the influence of ions from the salts, therefore resulting in the formation of large agglomerates [8-10] As a result, the nanoparticles ... rod-shaped The cells were sectioned and thus the shape is a function of the angle of each cell relative to the diamond knife during sectioning TEM images of cells grown in the absence of nanoparticles ... formvar) into dry powder using tweezers to hold the grid The sample grid was then lightly tapped to remove any excess particles, and the grid was placed in the TEM for imaging The silica and gold...
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Báo cáo y học: " Characterization of the bronchodilatory dose response to indacaterol in patients with chronic obstructive pulmonary disease using modelbased approaches" ppt
Ngày tải lên :
12/08/2014, 13:22
... Values are numbers of patients (the sum of totals across the columns for indacaterol dose and comparators is greater than the total number of patients randomized due to the inclusion of cross-over ... dose the response asymptotically approached a maximum plateau The majority of study results for doses of 75 μg and above exceeded the MCID of 120 mL (dotted line on the graph) The outcome of the ... included in this analysis The most striking feature of the plot is that the response to indacaterol at the plateau exceeds the response of all comparators In other words, doses of indacaterol 150 μg...
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Báo cáo y học: " Characterization of the innate immune response to chronic aspiration in a novel rodent model" ppsx
Ngày tải lên :
12/08/2014, 15:21
... left to the macrophage in the right lung is shown as a function of time In the inset, the ratio of macrophages in the left to the macrophages in the right lung is shown for all rats, regardless of ... IL-1alpha and IL-1beta by endothelial cells, fibroblasts, and macrophages can be profibrotic and not only exacerbates the inflammatory response, but also activates and stimulates proliferation of T and ... predispose recipients to acute and/ or chronic rejection The activation of TH1 immune pathways and the generation of a cytotoxic response has been associated with rejection in a number of lung allograft...
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Local immunopotentiation of the bladder in response to BCG immunotherapy
Ngày tải lên :
16/09/2015, 08:31
... group of cell cycle inhibitory molecules (see Fig 1.1) p16 together with p15 inhibit phosphorylation of the retinoblastoma protein (Rb), thereby inhibiting the cell cycle Loss of either of these ... dilution of the therapeutic agent by the continuous production of urine occurs and may reduce the effectiveness of chemotherapy (Au et al 2001) The most commonly used chemotherapeutic agents are the ... Th1 and Th2 cytokine response, with a predomination of TH1 cytokines The addition of interferon alpha to BCG induces xvi more urinary interferon gamma production, a cytokine known to increase the...
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báo cáo hóa học: " Wallerian degeneration: the innate-immune response to traumatic nerve injury" potx
Ngày tải lên :
19/06/2014, 22:20
... phagocytosis of degenerated myelin, and production of cytokines and chemokines) Special attention is given to the orchestration of these events with respect to their timing and magnitude, and to the identity ... phases at the injury site and further distal to it; the first peaks within hours and the second to days after the injury IL-1a, IL-1b and TNFa contribute to NGF mRNA upregulation in fibroblasts ... protein The second phase of IL-6 production develops and then peaks at day after the injury concomitant with the timing and magnitude of macrophage recruitment The production and secretion of the...
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Tài liệu Báo cáo khóa học: Quantitative analysis, using MALDI-TOF mass spectrometry, of the N-terminal hydrolysis and cyclization reactions of the activation 2 process of onconase pdf
Ngày tải lên :
19/02/2014, 12:20
... simplify the protocol and shorten the time needed to obtain a fully active ONC compared with other procedures described in the literature The application of MALDI-TOF MS to the characterization of ... this work for the activation of ONC has no detrimental effect on the conformational stability of the enzyme Cytotoxic activity The effect of (Met1) removal on the cytotoxic properties of ONC was ... dehydration, together with acidification and dilution of the samples, stopped the reactions This finding allowed the acquisition of spectra in the automatic mode, once all the samples had been taken and...
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Báo cáo khoa học: The 2-oxoacid dehydrogenase multi-enzyme complex of the archaeon Thermoplasma acidophilum ) recombinant expression, assembly and characterization docx
Ngày tải lên :
16/03/2014, 05:20
... decarboxylation of the 2-oxoacid and the transfer of the resulting acyl group to the lipoic acid of E2 E2 then transfers the acyl-group to coenzyme-A (CoASH), after which E3 serves to reoxidize the dihydrolipoyl ... using the program SEDFIT, and the data were then directly fitted using the finite element solution of the Lamm equation in SEDFIT [18] to give values of the sedimentation coefficient in the buffer of ... target lysine of which is flanked by D and V residues, as it is in the E2 protein of the E coli OGDHC and of the Bacillus subtilis BCOADHC (Fig 1) However, in addition to the identity of the neighbouring...
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Nature of the band gap of silicon and germanium nanowires
Ngày tải lên :
16/03/2014, 15:18
... Fig Band structure of (1 0), (1 0) and (1 1) Ge nanowires with D$20 A of the band gap and determines the overall nature of the nanowire band structure Si (100) Ge (100) where mà and mà are the ... G2X bulk band gap The Ge nanowires converge towards different band gaps: (1 0) towards the G2L gap, whereas (1 0) and (1 1) nanowires converge towards the G2X value Figs and show the band dispersion ... shows the distribution of the G, X and L states between the A and B planes in the (1 0), (1 0) and (1 1) unit cells In the (1 0) and (1 1) bulk unit cells, the X ðLÞ points are clearly on the A...
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Báo cáo khoa học: Monitoring the prevention of amyloid fibril formation by a-crystallin Temperature dependence and the nature of the aggregating species pdf
Ngày tải lên :
30/03/2014, 04:20
... fluorescence The subsequent plateau phase is associated with a decrease in the concentration of small species, or the aggregation and precipitation of fibrils [37] The kinetics of these three stages of the ... available on the effect of sHsps on the cytotoxicity of prefibrillar a-synuclein aggregates, however, the unrelated Hsp70 molecular chaperone reduces the toxicity of prefibrillar and misfolded detergent-insoluble ... enables the real time study of both fibril elongation and the initial nucleation processes By monitoring the thickness, average density and mass of the protein deposition layer, it was possible to...
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Báo cáo sinh học: "Molecular and cellular correlates of the CIITA-mediated inhibition of HTLV-2 Tax-2 transactivator function resulting in loss of viral replication" pot
Ngày tải lên :
18/06/2014, 22:20
... localization unveiled the co-localization of Tax-2 and CIITA both in the cytoplasm and the nucleus, and the role of CIITA in redirecting, upon binding, Tax-2 molecules mostly in the cytoplasm These results ... results and drafted the manuscript GT participated in the design and coordination of the study and in the discussion of the results RSA conceived the study, and participated in its design and coordination ... was analyzed in the presence and in the absence of CIITA In the absence of CIITA, Tax-2 localizes both and in the cytoplasm and in the nucleus of 293T cells often with a punctuated aspect (Figure...
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o cáo hóa học:" Molecular and cellular correlates of the CIITA-mediated inhibition of HTLV-2 Tax-2 transactivator function resulting in loss of viral replication" potx
Ngày tải lên :
20/06/2014, 04:20
... localization unveiled the co-localization of Tax-2 and CIITA both in the cytoplasm and the nucleus, and the role of CIITA in redirecting, upon binding, Tax-2 molecules mostly in the cytoplasm These results ... results and drafted the manuscript GT participated in the design and coordination of the study and in the discussion of the results RSA conceived the study, and participated in its design and coordination ... was analyzed in the presence and in the absence of CIITA In the absence of CIITA, Tax-2 localizes both and in the cytoplasm and in the nucleus of 293T cells often with a punctuated aspect (Figure...
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Báo cáo toán học: "Antioxidant, antimicrobial, and theoretical studies of the thiosemicarbazone derivative Schiff base 2-(2-imino-1-methylimidazolidin-4-ylidene)hydrazinecarbothioamide (IMHC)" potx
Ngày tải lên :
20/06/2014, 20:20
... Scheme Tautomerization of thione Scheme The synthesis of IMHC Figure Optimized 3D structure of the IMHC Figure The effect of test organism toward synthesized compound Figure The effect of tested ... across the C=N bond The existence of the thione form predominantly in the solid state is demonstrated by the presence of two absorption bands at 1273.7 and 3421 cm−1 belonging to the C=S and NH ... spectroscopy The FT-IR spectra provide valuable information regarding the nature of functional group of IMHC The appearance of a broad strong band in the IR spectra of IMHC in 3421 cm–1 is assigned to...
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Chapter 091. Benign and Malignant Diseases of the Prostate (Part 2) pot
Ngày tải lên :
07/07/2014, 02:20
... control, in which the tempo of the illness is altered and symptoms controlled until the patient dies of other causes These can be equivalent therapeutically from a patient standpoint if the patient ... experienced symptoms of the disease or the treatment needed to control it Even when a recurrence is documented, immediate therapy is not always necessary Rather, as at the time of diagnosis, the need ... diagnosis, the need for intervention is based on the tempo of the illness as it unfolds in the individual, relative to the riskto-benefit ratio of the therapy being considered No Cancer Diagnosis...
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Báo cáo y học: "The proinflammatory cytokines IL-2, IL-15 and IL-21 modulate the repertoire of mature human natural killer cell receptors" pot
Ngày tải lên :
09/08/2014, 10:22
... downregulate the expression of NKp44 receptor via the adaptor DAP-12 while preserving production of cytokines by the CD56bright and CD56dim subpopulations of NK cells and even enhancing their cytotoxic ... their cytotoxicity to K562 target cells Seven days of expansion with the different cytokine regimens did not reduce the cytotoxicity to K562 target cells of NK cell population The mean cytotoxic ... down-regulated the expression of C-lectin receptor NKG2D at the cell surface and the transcript of the adaptor DAP10 after days of culture with IL-15 The expression of DAP10 cDNA was normalized against the...
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Báo cáo y học: " Dimensionality and scale properties of the Edinburgh Depression Scale (EDS) in patients with type 2 diabetes mellitus: the DiaDDzoB study" pot
Ngày tải lên :
11/08/2014, 15:22
... were found between the factor loadings under the one-factor model and bifactor model Furthermore, the reliability of both the ten- item scale and the general factor under the bifactor model was 0.83 ... correlated two-factor model, in which items to 10 load on one factor and items and load on the other factor, and a onefactor model with items to 10 (having removed items and 2) Comparison of the fit indices ... uncorrelated and not correlate with the general factor Comparison of the item factor loadings under the full information one-factor model and the factor loadings under the full information bifactor model...
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